The perform of SIK1 in tumorigenesis. SIK1 is usually a tumor suppressor gene, which performs an important regulatory part in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 also can